The city of Perryville is located along the I-55, about 30 miles north of Cape Girardeau and about 70 miles south of St. Louis, Missouri.
The main attractions in the city are St. Mary's of the Barrens Historic District, Perry County Museum, the restored Faherty House and the historic Perry County Court house.
Hotels and motels in Perryville are located along the I-55 exist 129, within 3 miles of downtown.